Home · Skin Boosters
Injectable Bioremodelling
Skin Boosters
Not fillers. Not volume. Something more fundamental, injectable bioremodelling treatments that restore the skin's own hydration, elasticity and structural density at a cellular level. The results look like your skin, ten years ago.
What Are Skin Boosters?
The difference
between filling and remodelling.
The single most important distinction to understand when considering injectable skin treatments is the difference between a dermal filler and a skin booster. They share a delivery method, a needle, but their mechanism, their result and their purpose are fundamentally different.
Fillers add volume. They occupy space in the tissue, creating an immediate physical result by displacing adjacent structures. The skin itself is unchanged. When the filler degrades, the volume returns to its previous state.
Skin boosters remodel the extracellular matrix: the biological scaffolding of the dermis. They stimulate fibroblast activity, restore the skin's capacity to retain moisture, and trigger the production of structural proteins (collagen types I, III and IV, elastin) that declined with age. The skin itself is changed. The improvement is intrinsic, not additive.
Dermal Filler
Adds Volume
Physical displacement of tissue. Immediate result. No change to skin biology. Result reverses as filler degrades.
Skin Booster
Remodels Structure
Stimulates the skin's own collagen, elastin and hyaluronic acid production. Biological improvement that persists beyond the product's presence.
Visible as
Volume change
Immediate and visible. Associated with the "done" look when overdone.
Visible as
Quality change
Progressive over weeks. Skin looks like itself, but younger, denser and more luminous.
01
Profhilo
Profhilo Prices
Profhilo is the original and most extensively studied bioremodelling treatment, a unique hybrid of high and low molecular weight hyaluronic acid that spreads through the dermis on injection, triggering a biological cascade of collagen and elastin production rather than occupying space as a filler would.
Profhilo contains one of the highest concentrations of hyaluronic acid of any injectable product (64mg/2ml), but it is formulated as a pure, unstabilised HA, meaning it is not cross-linked like a filler. Instead of remaining localised at the injection site, Profhilo distributes through the tissue via a process called BDDE-free thermal bonding, spreading widely through the dermis and interacting with fibroblasts across a large tissue area.
The result of this interaction is a biological cascade: Profhilo stimulates the production of collagen types I, III and IV, as well as elastin and the proteins of the extracellular matrix. It does not add volume; it rebuilds the tissue's own structural scaffold, from the inside, over time.
The BAP technique: Profhilo is injected using five specific anatomical points per side of the face (the BAP, Bio Aesthetic Points), chosen to maximise distribution and avoid vascular structures. This technique takes approximately 15 minutes per session and results in minimal injection marks.
Areas treated: Face, neck, décolletage and hands, anywhere that skin quality, laxity and hydration are the primary concern. Profhilo is particularly effective for skin that appears tired, dull or crepey rather than volumetrically deflated.
The standard protocol is two sessions four weeks apart. Results continue to develop for up to three months following the second session as the collagen synthesis response matures. Maintenance sessions at six months sustain and compound the improvement.
Not a filler: Profhilo contains no volumising cross-links and produces no filler effect. If you need structural volume restoration (hollowed cheeks, deep tear troughs), a filler or PRF is more appropriate, discuss at consultation.
Treatment Details
Protocol
Two sessions 4 weeks apart. Maintenance at 6 months for sustained results.
Downtime
Minimal. Bio-activator bumps at injection points may persist for 24–48 hours. No activity restrictions.
Results timeline
Improvement begins approximately 4 weeks post-session 2. Full results at 3 months as collagen matures.
Duration
30 minutes per session including post-treatment review. No anaesthetic required.
02
Sunekos 200 / 1200
Sunekos Prices
Sunekos takes skin booster science one step further, combining hyaluronic acid with a patented amino acid complex that mirrors the exact building blocks of the extracellular matrix. Available in two formulations: Sunekos 200 for superficial work and Sunekos 1200 for deeper dermal remodelling and significant tissue restoration.
Sunekos 200 and 1200 share the same active ingredient concept, a patented combination of HA and six amino acids (glycine, L-proline, L-leucine, L-valine, L-lysine HCl and L-alanine), formulated to mimic the essential components of the extracellular matrix and directly supply the fibroblasts with the raw materials they need to produce new collagen and elastin.
The amino acid combination was developed through research into the specific amino acid profile of collagen and elastin, the two structural proteins that decline most significantly with ageing. By providing these amino acids directly to the fibroblasts alongside HA (which supports fibroblast activity), Sunekos triggers protein synthesis at a rate that HA alone cannot achieve.
Sunekos 200 uses a lower viscosity formulation designed for superficial injection, targeting fine lines, the periorbital area (under-eye hollowing, crow's feet), lip lines and superficial skin quality. Its lighter formula allows precise placement in delicate areas including the area directly under the eye, one of the most challenging zones in aesthetics.
Sunekos 1200 uses a higher concentration, more viscous formulation designed for deeper injection into areas with significant tissue loss or structural change, deeper lines, facial volumetric deflation and skin that has lost significant density and elasticity. Works alongside rather than instead of Sunekos 200 in comprehensive protocols.
Treatment Details
Protocol
Course of 4 sessions, 7–10 days apart initially. Maintenance 2–3 times per year.
Best for
Periorbital area, fine lines, lip lines, neck, hands and skin with early-to-moderate loss of quality and elasticity.
Downtime
Minimal. Small injection points resolve within hours. Some temporary swelling possible in delicate periorbital area.
Duration
30–45 minutes per session. Topical anaesthetic available if preferred.
03
Jalupro HMW
Jalupro Prices
Jalupro HMW (High Molecular Weight) is a dermal biorevitaliser combining hyaluronic acid with amino acids specifically formulated to stimulate fibroblast proliferation and restore dermal thickness, particularly effective for crepey, aged or photo-damaged skin where conventional bioremodellers have limited impact.
The HMW formulation refers to the molecular weight of the hyaluronic acid component, high molecular weight HA is less readily absorbed than low molecular weight variants, meaning it remains available to tissue for longer periods and provides sustained hydration and fibroblast stimulation. The amino acid complex (proline, glycine, leucine, lysine) supplies the fundamental building blocks for new collagen synthesis.
Jalupro HMW is particularly indicated for skin that has experienced significant photo-ageing (sun damage), for smokers' skin, and for clients with crepey or thin skin on the neck, décolletage and hands where the tissue has become fragile and lost structural integrity. It restores both dermal hydration and the density of the dermal scaffold.
The combination of fibroblast proliferation stimulation (producing more fibroblasts) and amino acid supply (giving those fibroblasts the materials they need) produces a synergistic effect on collagen output that sets Jalupro apart from single-mechanism products.
Treatment Details
Protocol
3 sessions, 2–3 weeks apart. Maintenance 1–2 times per year.
Best for
Photo-damaged skin, crepey skin, aged or thin skin on the neck, décolletage, face and hands.
Downtime
Minimal. Minor injection marks resolve within hours. Mild redness may persist for 24 hours.
Combines well with
Profhilo (Jalupro builds the scaffold; Profhilo maintains hydration and sustains the remodelling response).
04
Beautifeye HA135 Fillmed
Beautifeye Prices
Beautifeye HA135 is the only skin booster formulated specifically for the periorbital zone, the uniquely delicate, thin skin around the eyes that standard bioremodellers are not calibrated for. A cross-linked HA formulation at 135mg/ml, precisely engineered for periorbital application where other products risk adverse effects.
The skin around the eye is among the thinnest in the body, as little as 0.5mm compared to 2mm elsewhere on the face. This extreme delicacy means the periorbital area presents specific challenges for injectable treatment: conventional fillers are frequently associated with complications here (Tyndall effect, migration, overcorrection), and most bioremodellers are formulated for deeper, thicker skin and are not appropriate for injection in this zone.
Beautifeye HA135 is specifically formulated for this challenge. The concentration (135mg/ml), the degree of cross-linking, and the injection technique have all been designed for the periorbital anatomy, producing improvement in under-eye crepiness, tear trough hollowing (in mild presentations), fine lines and the overall quality of the periorbital skin without the risks associated with using standard fillers or bioremodellers in this zone.
What Beautifeye addresses: The under-eye area in early-to-moderate ageing, crepey, thin or dehydrated periorbital skin; superficial lines extending from the outer eye; the shadow effect from mild infraorbital hollowing. It does not replace filler for significant volumetric tear trough deficiency, a thorough consultation will clarify which approach is appropriate for your specific anatomy.
Periorbital treatment requires specialist skill: Injecting around the eye demands thorough knowledge of periorbital anatomy and significant clinical experience. All periorbital injectable treatments at Aesthetics Medispa are performed with this precision and care as the absolute priority.
Treatment Details
Protocol
3 sessions, 4 weeks apart. Maintenance at 6–9 months.
Downtime
Minimal bruising possible (periorbital skin is fragile). Mild swelling for 24–48 hours. Arnica recommended post-treatment.
Best for
Crepey under-eye skin, fine periorbital lines, mild infraorbital hollowing, thin or dehydrated periorbital skin.
Not suitable for
Significant tear trough volume loss, PRF or specific filler is more appropriate. Assessed at consultation.
At a Glance
Choosing the right product
| Product | Mechanism | Best for | Protocol | Longevity |
|---|---|---|---|---|
| Profhilo | HA bioremodelling, spreads widely, triggers collagen I/III/IV + elastin | Generalised skin quality, laxity, dullness, face, neck, décolletage, hands | 2 sessions, 4 weeks apart | 6–9 months |
| Sunekos 200 | HA + amino acids, fibroblast stimulation, ECM repair | Fine lines, periorbital, lip lines, superficial skin quality | 4 sessions, weekly–fortnightly | 4–6 months |
| Sunekos 1200 | Higher concentration HA + amino acids, deeper dermal remodelling | Significant tissue loss, deeper lines, moderate-to-advanced ageing | 4 sessions in course | 4–6 months |
| Jalupro HMW | HMW HA + amino acids, fibroblast proliferation, scaffold restoration | Photo-damaged, crepey, thin or aged skin, especially neck and décolletage | 3 sessions, 2–3 weeks apart | 6 months |
| Beautifeye HA135 | Calibrated cross-linked HA for periorbital anatomy | Under-eye crepiness, periorbital lines, mild tear trough | 3 sessions, 4 weeks apart | 6–9 months |
Your skin. Restored.
The right product for your skin, your age and your concern, determined at a thorough consultation before any treatment is recommended.